Synthetic Blood Vessels Grown by Researchers

Synthetic blood vessels that can be made in advance and stored until surgery could help patients undergoing heart surgery, hemodialysis—cleansing of the blood in cases of kidney failure—and other procedures. Laura Niklason, an anesthesiologist and biomedical engineer at Yale University, and her collaborators have grown blood vessels using human cells and tested them in baboons, showing that they provoke no immune rejection and avoid common complications of synthetic vessels, such as clotting, bursting, or contracting over time. Researchers hope these studies will show that the vessels are safe enough to win permission from the U.S. Food and Drug Administration to begin clinical trials.

During bypass surgery, doctors looking to circumvent blocked arteries usually harvest vessels from a patient's leg or arm. But people who suffer from vascular disease or who have had previous procedures may have no suitable vessels left. The other options have complications: grafts from donors are often rejected by the recipient's immune system, artificial plastic vessels have high rates of blood clots and other problems, and vessels grown from a patient's own tissue take more than six months to mature. "Artificial grafts suffer from clotting and obstruction because they are not tissue," says Niklason, especially when plastic is used.

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